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    IONIS PHARMACEUTICALS INC (IONS)
    Income
    Balance Sheet
    Market Cap
    $13B
    Latest price
    $79.57
    2.5%
    Dollar Amounts
    USD (Millions)
    Metric20202021202220232024
    Revenue$290$440$152$325$227
    Gross Profit$278$429$138$315$215
    Operating Income-$172-$30-$410-$354-$475
    Net Income-$451-$29-$270-$366-$454
    Showing latest financials
    Data in millions of USD
    Doing some research...

    Commentary on IONIS PHARMACEUTICALS, INC. Performance

    Over the five-year period, Ionis Pharmaceuticals’ financial performance has been notably volatile. In 2020, the company generated approximately $290.3 million in revenue and achieved a gross profit of around $278.3 million, but it struggled with significant operating and net losses (–$172.1 million and –$451.3 million, respectively). In 2021, revenue increased by roughly 51%, reaching $440.0 million, and gross profit expanded to $429.2 million. Notably, operating income improved dramatically, with losses narrowing to –$30.2 million, and net income turned much less negative at –$28.6 million. This turnaround in 2021 might be attributed to operational efficiencies or a favorable shift in product mix within the competitive biopharmaceutical sector. However, the subsequent years reveal marked swings: in 2022, revenue dropped by nearly 65% to $151.9 million, accompanied by a commensurate contraction in gross profit to $137.8 million and a steep deterioration in operating income (–$410.2 million). In 2023, revenue rebounded to $324.5 million and gross profit followed suit, rising to $315.4 million, yet operating losses remained sizable at –$353.7 million. The pattern continued into 2024 with revenue dipping to $226.6 million and gross profit to $215.4 million, while operating results further deteriorated (–$475.1 million) and net income hovered at significant losses (–$453.9 million). Overall, while there was a positive shift in 2021, the recurring large swings—particularly in revenue and operating metrics—suggest persistent challenges in achieving stable profitability, raising concerns about the company’s medium-term financial sustainability in a highly competitive, innovation-driven industry.

    This analysis is for informational purposes only and does not constitute financial advice or recommendations for any investment decisions. Please consult with a qualified financial professional for personalized guidance.